SERM
Estrogen-dependent cancers, such as breast and ovarian cancers, are influenced by the presence of estrogen in the body. Treatment for these types of cancers often involves medications that target estrogen receptors or reduce estrogen levels. Here are some classes of drugs commonly used in estrogen-dependent cancer treatment: 1. **Selective Estrogen Receptor Modulators (SERMs):** - Tamoxifen: Used primarily in breast cancer treatment. It acts as an estrogen receptor antagonist in breast tissue, blocking the effects of estrogen. - Raloxifene: Initially developed for osteoporosis, it also has anti-estrogenic effects and is used for breast cancer risk reduction. 2. **Aromatase Inhibitors (AIs):** - Anastrozole, Letrozole, Exemestane: These drugs block the conversion of androgens into estrogens in postmenopausal women, reducing estrogen levels. They are mainly used in postmenopausal women with hormone receptor-positive breast cancer. 3. **Gonadotropin-R...